Spravato® (Esketamine Therapy)
An FDA-approved treatment for treatment-resistant depression administered under medical supervision.
What Is Spravato® (Esketamine Therapy)?
Spravato® (esketamine) is an FDA-approved nasal spray for adults with treatment-resistant depression or major depressive disorder with suicidal ideation. It works differently than traditional antidepressants — targeting the NMDA receptor system to help restore neural connections that depression has disrupted.
At Mind Dojo, Spravato® is administered in a certified clinical setting under direct medical supervision. Every session follows a strict REMS (Risk Evaluation and Mitigation Strategy) protocol. This isn't an alternative treatment — it's a rigorously regulated, evidence-based option for people who haven't responded to conventional approaches.
Available in person at our Monroeville (3623 William Penn Hwy) and Irwin (8958 Hill Dr) locations. Call or text (412) 899-1402.
If you or a loved one is in immediate danger or may cause harm, call 988, call 911, or go to the nearest emergency room.
Who It's For
- Adults with treatment-resistant depression (failed 2+ antidepressants)
- Individuals with major depressive disorder and acute suicidal ideation
- Clients who have not responded adequately to oral medications
- Those seeking FDA-approved alternatives to traditional antidepressants
How It Works
- Self-administered nasal spray under clinician supervision
- Sessions last approximately 2 hours (including monitoring)
- Administered twice weekly for the first month, then weekly/biweekly
- Targets NMDA receptors to promote neural pathway restoration
- Used in conjunction with an oral antidepressant
Safety & Protocol
- Administered only in a REMS-certified clinical setting
- Blood pressure monitoring before, during, and after treatment
- 2-hour post-administration observation period required
- Clients cannot drive on the day of treatment
- Ongoing assessment of response and side effects
Your Path Forward
Eligibility Assessment
Our psychiatric team evaluates your treatment history, current medications, and clinical profile to determine if Spravato® is appropriate.
Insurance Authorization
We work with your insurance to obtain prior authorization. Most major plans cover Spravato® for qualifying clients.
Treatment Sessions
You'll come to our Monroeville or Irwin location for each session. The nasal spray is self-administered under supervision, followed by a 2-hour monitoring period.
Ongoing Evaluation
Your psychiatrist tracks your response, adjusts the treatment schedule, and coordinates with your broader care team.
Take the First Step
Whether you're ready to begin or just exploring your options — we're here to help.
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